PIN1 (NM_006221) - peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 1

Mutations Visualisation

Protein summary

This is preferred isoform of PIN1 protein.
PIN1: peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Description:

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011].

Strand
+
Chromosome
19
Protein
163 residues
All mutations
18
PTM sites
14
CDS
9,946,020 - 9,959,875
Transcription
9,945,882 - 9,960,365
1.84% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5300
Uniprot
Ensembl