PRKAA2 (NM_006252) - protein kinase AMP-activated catalytic subunit alpha 2

5'-Amp-Activated Protein Kinase Catalytic Subunit Alpha-2

Mutations Visualisation

Protein summary

This is preferred isoform of PRKAA2 protein.
PRKAA2: 5'-AMP-activated protein kinase catalytic subunit alpha-2

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments.

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: AK314011.1, SRR1803616.173171.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348]

552 residues
All mutations
PTM sites
57,111,060 - 57,173,386
57,110,989 - 57,181,008
20.65% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
gene: 5563