PRKAB1 (NM_006253) - protein kinase AMP-activated non-catalytic subunit beta 1

5'-Amp-Activated Protein Kinase Subunit Beta-1

Mutations Visualisation

Protein summary

This is preferred isoform of PRKAB1 protein.
PRKAB1: 5'-AMP-activated protein kinase subunit beta-1
Description:

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: AF022116.1, SRR1163655.468227.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348]

Strand
+
Chromosome
12
Protein
270 residues
All mutations
37
PTM sites
23
CDS
120,106,049 - 120,118,130
Transcription
120,105,760 - 120,119,429
31.48% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5564
Uniprot
Ensembl