KAT6A (NM_006766) - lysine acetyltransferase 6A

Histone Acetyltransferase Kat6a Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of KAT6A protein. View all 2 isoforms
KAT6A: histone acetyltransferase KAT6A isoform 1
Description:

This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].

Strand
-
Chromosome
8
Protein
2004 residues
All mutations
282
PTM sites
42
CDS
41,789,722 - 41,906,495
Transcription
41,786,996 - 41,909,544
74.4% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 7994
Uniprot
Ensembl