SUPT16H (NM_007192) - SPT16 homolog, facilitates chromatin remodeling subunit

Fact Complex Subunit Spt16

Mutations Visualisation

Protein summary

This is preferred isoform of SUPT16H protein.
SUPT16H: FACT complex subunit SPT16
Description:

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: SRR1660805.157934.1, SRR1660805.146067.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]

Strand
-
Chromosome
14
Protein
1047 residues
All mutations
104
PTM sites
66
CDS
21,820,831 - 21,852,086
Transcription
21,819,630 - 21,852,425
29.23% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 11198
Uniprot
Ensembl