You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

ICOS (NM_012092) - inducible T cell costimulator

Inducible T-Cell Costimulator Precursor

Mutations Visualisation

Protein summary

This is preferred isoform of ICOS protein.
ICOS: inducible T-cell costimulator precursor
Description:

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: BC028210.1, AB023135.1 [ECO:0000332]

##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000316386.11/ ENSP00000319476.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

Strand
+
Chromosome
2
Protein
199 residues
All mutations
40
PTM sites
1
CDS
204,801,537 - 204,824,322
Transcription
204,801,470 - 204,826,298
7.04% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 29851
UniProt
Ensembl