PPP2R1A (NM_014225) - protein phosphatase 2 scaffold subunit Aalpha

Serine/threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform

Mutations Visualisation

Protein summary

This is preferred isoform of PPP2R1A protein.
PPP2R1A: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Description:

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].

Strand
+
Chromosome
19
Protein
589 residues
All mutations
94
PTM sites
30
CDS
52,693,349 - 52,729,234
Transcription
52,693,054 - 52,729,678
1.36% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5518
Uniprot
Ensembl