You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

DAZAP2 (NM_014764) - DAZ associated protein 2

Daz-Associated Protein 2 Isoform A

Mutations Visualisation

Protein summary

This is preferred isoform of DAZAP2 protein. View all 6 isoforms
DAZAP2: DAZ-associated protein 2 isoform a
Description:

This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].

Strand
+
Chromosome
12
Protein
168 residues
All mutations
25
PTM sites
3
CDS
51,632,691 - 51,636,242
Transcription
51,632,507 - 51,637,717
79.76% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 9802
UniProt
Ensembl