PPP1R13B (NM_015316) - protein phosphatase 1 regulatory subunit 13B

Apoptosis-Stimulating Of P53 Protein 1

Mutations Visualisation

Protein summary

This is preferred isoform of PPP1R13B protein.
PPP1R13B: apoptosis-stimulating of p53 protein 1
Description:

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: BC035446.1, AJ318887.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]

Strand
-
Chromosome
14
Protein
1090 residues
All mutations
159
PTM sites
12
CDS
104,201,490 - 104,313,644
Transcription
104,200,087 - 104,313,927
65.6% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 23368
Uniprot
Ensembl