PRKAG2 (NM_016203) - protein kinase AMP-activated non-catalytic subunit gamma 2

5'-Amp-Activated Protein Kinase Subunit Gamma-2 Isoform A

Mutations Visualisation

Protein summary

This is preferred isoform of PRKAG2 protein. View all 5 isoforms
PRKAG2: 5'-AMP-activated protein kinase subunit gamma-2 isoform a
Description:

AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015].

Strand
-
Chromosome
7
Protein
569 residues
All mutations
117
PTM sites
39
CDS
151,254,286 - 151,573,705
Transcription
151,253,200 - 151,574,316
40.77% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 51422
Uniprot
Ensembl