UBB (NM_018955) - ubiquitin B

Polyubiquitin-B Precursor

Mutations Visualisation

Protein summary

This is preferred isoform of UBB protein. View all 6 isoforms
UBB: polyubiquitin-B precursor
Description:

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].

Strand
+
Chromosome
17
Protein
229 residues
All mutations
9
PTM sites
48
CDS
16,285,221 - 16,285,911
Transcription
16,284,110 - 16,286,059
0.0% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 7314
Uniprot
Ensembl