RNF34 (NM_025126) - ring finger protein 34

E3 Ubiquitin-Protein Ligase Rnf34 Isoform 2

Mutations Visualisation

Protein summary

This is preferred isoform of RNF34 protein. View all 3 isoforms
RNF34: E3 ubiquitin-protein ligase RNF34 isoform 2
Description:

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012].

Strand
+
Chromosome
12
Protein
372 residues
All mutations
46
PTM sites
10
CDS
121,838,015 - 121,861,379
Transcription
121,837,885 - 121,862,155
38.17% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 80196
Uniprot
Ensembl