MAPKAPK5 (NM_139078) - mitogen-activated protein kinase-activated protein kinase 5

Map Kinase-Activated Protein Kinase 5 Isoform 2

Mutations Visualisation

Protein summary

This is preferred isoform of MAPKAPK5 protein. View all 2 isoforms
MAPKAPK5: MAP kinase-activated protein kinase 5 isoform 2
Description:

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012].

Strand
+
Chromosome
12
Protein
473 residues
All mutations
57
PTM sites
8
CDS
112,280,537 - 112,330,865
Transcription
112,280,031 - 112,331,228
7.4% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 8550
Uniprot
Ensembl