PRR5 (NM_181333) - proline rich 5

Proline-Rich Protein 5 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of PRR5 protein. View all 6 isoforms
PRR5: proline-rich protein 5 isoform 1
Description:

This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010].

Strand
+
Chromosome
22
Protein
388 residues
All mutations
74
PTM sites
12
CDS
45,098,354 - 45,133,127
Transcription
45,098,077 - 45,133,561
38.66% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 55615
Uniprot
Ensembl