RFC2 (NM_181471) - replication factor C subunit 2

Replication Factor C Subunit 2 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of RFC2 protein. View all 5 isoforms
RFC2: replication factor C subunit 2 isoform 1
Description:

This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013].

Strand
-
Chromosome
7
Protein
354 residues
All mutations
53
PTM sites
13
CDS
73,646,435 - 73,668,713
Transcription
73,645,831 - 73,668,788
9.89% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5982
Uniprot
Ensembl