You are viewing an old version (2017) of the ActiveDriverDB. To access the new (2020) version click here.

PTPN11 (NM_002834) - protein tyrosine phosphatase, non-receptor type 11

Tyrosine-Protein Phosphatase Non-Receptor Type 11 Isoform 1

PTM Interaction Network Visualisation

Protein summary

This is preferred isoform of PTPN11 protein. View all 2 isoforms
PTPN11: tyrosine-protein phosphatase non-receptor type 11 isoform 1

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016].

593 residues
All mutations
PTM sites
112,856,915 - 112,942,568
112,856,535 - 112,947,717
8.09% of sequence is predicted to be disordered

Usage summary


drag the background to move whole network
scroll to zoom in and out

PTM site

double click to focus on site's sub-network (or hide it)

Kinases group

double click to show/hide all kinases within the group.

Kinase, PTM site or protein

hover to see a tooltip with additional information
click to stick the tooltip
drag a node to move it and stick in a chosen place
shift + click to free a node which was stuck earlier

External references

Mappings retrieved from NCBI & Uniprot.
gene: 5781