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Mutation:
TP53 T125M
Summary
Isoform:
Position:
125
Ref:
T
Mutation:
M
PTM impact:
proximal
PTM affected:
3
Kinases:
SRC
Clinical Information
Cancer types: (TCGA MC3)
OV, HNSC, STAD
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 120K
Affected site:
Position: 120
Residue: K
Type: ubiquitination, acetylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 120E | FLHSGTA[K/E]KSVTCTYS | 0 |
direct
|
| 121P | FLHSGTAK[S/P]SVTCTYS | 1 |
proximal
|
| 119G | FLHSGT[A/G]AKSVTCTYS | 1 |
proximal
|
| 119P | FLHSGT[A/P]AKSVTCTYS | 1 |
proximal
|
| 121Y | FLHSGTAK[S/Y]SVTCTYS | 1 |
proximal
|
PTM Site: 126Y
Affected site:
Position: 126
Residue: Y
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 126C | AKSVTCT[Y/C]YSPALNKM | 0 |
direct
|
| 126D | AKSVTCT[Y/D]YSPALNKM | 0 |
direct
|
| 126N | AKSVTCT[Y/N]YSPALNKM | 0 |
direct
|
| 126H | AKSVTCT[Y/H]YSPALNKM | 0 |
direct
|
| 126S | AKSVTCT[Y/S]YSPALNKM | 0 |
direct
|
PTM Site: 132K
Affected site:
Position: 132
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 132N | TYSPALN[K/N]KMFCQLAK | 0 |
direct
|
| 132M | TYSPALN[K/M]KMFCQLAK | 0 |
direct
|
| 132R | TYSPALN[K/R]KMFCQLAK | 0 |
direct
|
| 132T | TYSPALN[K/T]KMFCQLAK | 0 |
direct
|
| 132E | TYSPALN[K/E]KMFCQLAK | 0 |
direct
|
External references
dbSNP:
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