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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

TP53 A119G

Summary

Isoform:
NM_000546
Position:
119
Ref:
A
Mutation:
G
PTM impact:
proximal
PTM affected:
3
Kinases:
SRC

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Li-Fraumeni syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 115H

Affected site:

Position: 115
Residue: H
Type: methylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
121P GFRLGFLHSGTAK[S/P]SV 6
distal
120E GFRLGFLHSGTA[K/E]KSV 5
distal
119G GFRLGFLHSGT[A/G]AKSV 4
distal
119P GFRLGFLHSGT[A/P]AKSV 4
distal
118I GFRLGFLHSG[T/I]TAKSV 3
distal
117V GFRLGFLHS[G/V]GTAKSV 2
proximal
117R GFRLGFLHS[G/R]GTAKSV 2
proximal
116A GFRLGFLH[S/A]SGTAKSV 1
proximal
115R GFRLGFL[H/R]HSGTAKSV 0
direct
115N GFRLGFL[H/N]HSGTAKSV 0
direct
114S GFRLGF[L/S]LHSGTAKSV 1
proximal
113C GFRLG[F/C]FLHSGTAKSV 2
proximal
113S GFRLG[F/S]FLHSGTAKSV 2
proximal
113V GFRLG[F/V]FLHSGTAKSV 2
proximal
112S GFRL[G/S]GFLHSGTAKSV 3
distal
111R GFR[L/R]LGFLHSGTAKSV 4
distal
111P GFR[L/P]LGFLHSGTAKSV 4
distal
111Q GFR[L/Q]LGFLHSGTAKSV 4
distal
111M GFR[L/M]LGFLHSGTAKSV 4
distal
110L GF[R/L]RLGFLHSGTAKSV 5
distal
110P GF[R/P]RLGFLHSGTAKSV 5
distal
110H GF[R/H]RLGFLHSGTAKSV 5
distal
110C GF[R/C]RLGFLHSGTAKSV 5
distal
110G GF[R/G]RLGFLHSGTAKSV 5
distal
110S GF[R/S]RLGFLHSGTAKSV 5
distal
109C G[F/C]FRLGFLHSGTAKSV 6
distal
109V G[F/V]FRLGFLHSGTAKSV 6
distal
113L GFRLG[F/L]FLHSGTAKSV 2
proximal
109S G[F/S]FRLGFLHSGTAKSV 6
distal
121Y GFRLGFLHSGTAK[S/Y]SV 6
distal
113I GFRLG[F/I]FLHSGTAKSV 2
proximal

PTM Site: 120K

Affected site:

Position: 120
Residue: K
Type: ubiquitination, acetylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
126C FLHSGTAKSVTCT[Y/C]YS 6
distal
126D FLHSGTAKSVTCT[Y/D]YS 6
distal
126N FLHSGTAKSVTCT[Y/N]YS 6
distal
125M FLHSGTAKSVTC[T/M]TYS 5
distal
125R FLHSGTAKSVTC[T/R]TYS 5
distal
125K FLHSGTAKSVTC[T/K]TYS 5
distal
125P FLHSGTAKSVTC[T/P]TYS 5
distal
124G FLHSGTAKSVT[C/G]CTYS 4
distal
124S FLHSGTAKSVT[C/S]CTYS 4
distal
123I FLHSGTAKSV[T/I]TCTYS 3
distal
122M FLHSGTAKS[V/M]VTCTYS 2
proximal
121P FLHSGTAK[S/P]SVTCTYS 1
proximal
120E FLHSGTA[K/E]KSVTCTYS 0
direct
119G FLHSGT[A/G]AKSVTCTYS 1
proximal
119P FLHSGT[A/P]AKSVTCTYS 1
proximal
118I FLHSG[T/I]TAKSVTCTYS 2
proximal
117V FLHS[G/V]GTAKSVTCTYS 3
distal
117R FLHS[G/R]GTAKSVTCTYS 3
distal
116A FLH[S/A]SGTAKSVTCTYS 4
distal
115R FL[H/R]HSGTAKSVTCTYS 5
distal
115N FL[H/N]HSGTAKSVTCTYS 5
distal
114S F[L/S]LHSGTAKSVTCTYS 6
distal
126H FLHSGTAKSVTCT[Y/H]YS 6
distal
126S FLHSGTAKSVTCT[Y/S]YS 6
distal
121Y FLHSGTAK[S/Y]SVTCTYS 1
proximal

PTM Site: 126Y

Affected site:

Position: 126
Residue: Y
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
132N AKSVTCTYSPALN[K/N]KM 6
distal
132M AKSVTCTYSPALN[K/M]KM 6
distal
132R AKSVTCTYSPALN[K/R]KM 6
distal
132T AKSVTCTYSPALN[K/T]KM 6
distal
132E AKSVTCTYSPALN[K/E]KM 6
distal
132Q AKSVTCTYSPALN[K/Q]KM 6
distal
131K AKSVTCTYSPAL[N/K]NKM 5
distal
131I AKSVTCTYSPAL[N/I]NKM 5
distal
131Y AKSVTCTYSPAL[N/Y]NKM 5
distal
130P AKSVTCTYSPA[L/P]LNKM 4
distal
130H AKSVTCTYSPA[L/H]LNKM 4
distal
130F AKSVTCTYSPA[L/F]LNKM 4
distal
130V AKSVTCTYSPA[L/V]LNKM 4
distal
129G AKSVTCTYSP[A/G]ALNKM 3
distal
129S AKSVTCTYSP[A/S]ALNKM 3
distal
129T AKSVTCTYSP[A/T]ALNKM 3
distal
128L AKSVTCTYS[P/L]PALNKM 2
proximal
128T AKSVTCTYS[P/T]PALNKM 2
proximal
127F AKSVTCTY[S/F]SPALNKM 1
proximal
127C AKSVTCTY[S/C]SPALNKM 1
proximal
127Y AKSVTCTY[S/Y]SPALNKM 1
proximal
127P AKSVTCTY[S/P]SPALNKM 1
proximal
127T AKSVTCTY[S/T]SPALNKM 1
proximal
126C AKSVTCT[Y/C]YSPALNKM 0
direct
126D AKSVTCT[Y/D]YSPALNKM 0
direct
126N AKSVTCT[Y/N]YSPALNKM 0
direct
125M AKSVTC[T/M]TYSPALNKM 1
proximal
125R AKSVTC[T/R]TYSPALNKM 1
proximal
125K AKSVTC[T/K]TYSPALNKM 1
proximal
125P AKSVTC[T/P]TYSPALNKM 1
proximal
124G AKSVT[C/G]CTYSPALNKM 2
proximal
124S AKSVT[C/S]CTYSPALNKM 2
proximal
123I AKSV[T/I]TCTYSPALNKM 3
distal
122M AKS[V/M]VTCTYSPALNKM 4
distal
121P AK[S/P]SVTCTYSPALNKM 5
distal
120E A[K/E]KSVTCTYSPALNKM 6
distal
126H AKSVTCT[Y/H]YSPALNKM 0
direct
126S AKSVTCT[Y/S]YSPALNKM 0
direct
130R AKSVTCTYSPA[L/R]LNKM 4
distal
131S AKSVTCTYSPAL[N/S]NKM 5
distal
121Y AK[S/Y]SVTCTYSPALNKM 5
distal

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