PDE3A D552V

You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

Mutation:

Summary

Isoform:

NM_000921

Position:

552

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0077]

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 550S

Affected site:

Position: 550

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
552V	SAVQFPESA[D/V]DTTAKQ	2	proximal
546E	SAV[Q/E]QFPESADTTAKQ	4	distal
549Q	SAVQFP[E/Q]ESADTTAKQ	1	proximal

PTM Site: 553T

Affected site:

Position: 553

Residue: T

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
552V	QFPESA[D/V]DTTAKQSLG	1	proximal
559R	QFPESADTTAKQS[L/R]LG	6	distal
549Q	QFP[E/Q]ESADTTAKQSLG	4	distal

PTM Site: 554T

Affected site:

Position: 554

Residue: T

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
552V	FPESA[D/V]DTTAKQSLGS	2	proximal
559R	FPESADTTAKQS[L/R]LGS	5	distal
549Q	FP[E/Q]ESADTTAKQSLGS	5	distal

PTM Site: 556K

Affected site:

Position: 556

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
552V	ESA[D/V]DTTAKQSLGSHR	4	distal
559R	ESADTTAKQS[L/R]LGSHR	3	distal

PTM Site: 558S

Affected site:

Position: 558

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
552V	A[D/V]DTTAKQSLGSHRAL	6	distal
559R	ADTTAKQS[L/R]LGSHRAL	1	proximal

If you have any questions or feedback about this mutation: