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Mutation:

TMPO S159F

Summary

Isoform:
NM_001032283
Position:
159
Ref:
S
Mutation:
F
PTM impact:
direct
PTM affected:
7
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

[0.0199681]

PTM Site: 154T

Affected site:

Position: 154
Residue: T
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
159F LKLREQGTESRS[S/F]STP 5
distal

PTM Site: 156S

Affected site:

Position: 156
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
159F LREQGTESRS[S/F]STPLP 3
distal

PTM Site: 158S

Affected site:

Position: 158
Residue: S
Type: phosphorylation

Only gain of PTM site:

PDPK1 (probability p=0.92)
Site: 158S (phosphorylation)
Position in motif: 1

Other known mutations affecting this site

Mutation In sequence Distance Impact
159F EQGTESRS[S/F]STPLPTI 1
network-rewiring

PTM Site: 159S

Affected site:

Position: 159
Residue: S
Type: phosphorylation

Impact:

direct

Other known mutations affecting this site

Mutation In sequence Distance Impact
159F QGTESRS[S/F]STPLPTIS 0
direct

PTM Site: 160T

Affected site:

Position: 160
Residue: T
Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
166Y GTESRSSTPLPTI[S/Y]SS 6
distal
166C GTESRSSTPLPTI[S/C]SS 6
distal
159F GTESRS[S/F]STPLPTISS 1
proximal

PTM Site: 164T

Affected site:

Position: 164
Residue: T
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
166Y RSSTPLPTI[S/Y]SSSAEN 2
proximal
166C RSSTPLPTI[S/C]SSSAEN 2
proximal
159F RS[S/F]STPLPTISSSAEN 5
distal
170Q RSSTPLPTISSSA[E/Q]EN 6
distal

PTM Site: 166S

Affected site:

Position: 166
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
166Y STPLPTI[S/Y]SSSAENTR 0
direct
166C STPLPTI[S/C]SSSAENTR 0
direct
170Q STPLPTISSSA[E/Q]ENTR 4
distal

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