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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

TMPO E170Q

Summary

Isoform:
NM_001032283
Position:
170
Ref:
E
Mutation:
Q
PTM impact:
network-rewiring
PTM affected:
6
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

BRCA

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 164T

Affected site:

Position: 164
Residue: T
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
166Y RSSTPLPTI[S/Y]SSSAEN 2
proximal
166C RSSTPLPTI[S/C]SSSAEN 2
proximal
159F RS[S/F]STPLPTISSSAEN 5
distal
170Q RSSTPLPTISSSA[E/Q]EN 6
distal

PTM Site: 166S

Affected site:

Position: 166
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
166Y STPLPTI[S/Y]SSSAENTR 0
direct
166C STPLPTI[S/C]SSSAENTR 0
direct
170Q STPLPTISSSA[E/Q]ENTR 4
distal

PTM Site: 167S

Affected site:

Position: 167
Residue: S
Type: phosphorylation

Best loss of PTM site:

CSNK2A1 (probability p=0.938)
Site: 167S (phosphorylation)
Position in motif: 3
There is 1 other predicted loss:
  • PLK1 (p=0.9)

Other known mutations affecting this site

Mutation In sequence Distance Impact
166Y TPLPTI[S/Y]SSSAENTRQ 1
proximal
166C TPLPTI[S/C]SSSAENTRQ 1
proximal
170Q TPLPTISSSA[E/Q]ENTRQ 3
network-rewiring

PTM Site: 168S

Affected site:

Position: 168
Residue: S
Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
166Y PLPTI[S/Y]SSSAENTRQN 2
proximal
166C PLPTI[S/C]SSSAENTRQN 2
proximal
170Q PLPTISSSA[E/Q]ENTRQN 2
proximal
174H PLPTISSSAENTR[Q/H]QN 6
distal

PTM Site: 172T

Affected site:

Position: 172
Residue: T
Type: phosphorylation

Best loss of PTM site:

CSNK2A1 (probability p=0.938)
Site: 167S (phosphorylation)
Position in motif: 3
There is 1 other predicted loss:
  • PLK1 (p=0.9)

Other known mutations affecting this site

Mutation In sequence Distance Impact
166Y I[S/Y]SSSAENTRQNGSND 6
distal
166C I[S/C]SSSAENTRQNGSND 6
distal
177G ISSSAENTRQNG[S/G]SND 5
distal
170Q ISSSA[E/Q]ENTRQNGSND 2
network-rewiring
174H ISSSAENTR[Q/H]QNGSND 2
proximal

PTM Site: 177S

Affected site:

Position: 177
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
177G ENTRQNG[S/G]SNDSDRYS 0
direct
174H ENTR[Q/H]QNGSNDSDRYS 3
distal

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