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Summary

Isoform:
Position:
117
Ref:
R
Mutation:
K
PTM impact:
network-rewiring
PTM affected:
3
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

SKCM

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 119S

Affected site:

Position: 119
Residue: S
Type: phosphorylation

Best loss of PTM site:

AKT1 (probability p=0.949)
Site: 122S (phosphorylation)
Position in motif: -5
There is 1 other predicted loss:
  • PRKCD (p=0.887)

Other known mutations affecting this site

Mutation In sequence Distance Impact
120F SRSPKRRS[V/F]VSSQRSR 1
proximal
118I SRSPKR[R/I]RSVSSQRSR 1
proximal
125F SRSPKRRSVSSQR[S/F]SR 6
distal
117K SRSPK[R/K]RRSVSSQRSR 2
network-rewiring
120L SRSPKRRS[V/L]VSSQRSR 1
proximal
124S SRSPKRRSVSSQ[R/S]RSR 5
distal

PTM Site: 121S

Affected site:

Position: 121
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
120F SPKRRS[V/F]VSSQRSRSR 1
proximal
118I SPKR[R/I]RSVSSQRSRSR 3
network-rewiring
125F SPKRRSVSSQR[S/F]SRSR 4
distal
117K SPK[R/K]RRSVSSQRSRSR 4
distal
120L SPKRRS[V/L]VSSQRSRSR 1
proximal
124S SPKRRSVSSQ[R/S]RSRSR 3
network-rewiring

PTM Site: 122S

Affected site:

Position: 122
Residue: S
Type: phosphorylation

Best loss of PTM site:

AKT1 (probability p=0.949)
Site: 122S (phosphorylation)
Position in motif: -5
There is 1 other predicted loss:
  • PRKCD (p=0.887)

Other known mutations affecting this site

Mutation In sequence Distance Impact
128K PKRRSVSSQRSRS[R/K]RS 6
distal
128I PKRRSVSSQRSRS[R/I]RS 6
distal
120F PKRRS[V/F]VSSQRSRSRS 2
proximal
118I PKR[R/I]RSVSSQRSRSRS 4
distal
125F PKRRSVSSQR[S/F]SRSRS 3
network-rewiring
117K PK[R/K]RRSVSSQRSRSRS 5
network-rewiring
120L PKRRS[V/L]VSSQRSRSRS 2
proximal
124S PKRRSVSSQ[R/S]RSRSRS 2
network-rewiring

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