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Summary

Isoform:
Position:
128
Ref:
R
Mutation:
K
PTM impact:
distal
PTM affected:
6
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

LUAD

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 121S

Affected site:

Position: 121
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
120F SPKRRS[V/F]VSSQRSRSR 1
proximal
118I SPKR[R/I]RSVSSQRSRSR 3
network-rewiring
125F SPKRRSVSSQR[S/F]SRSR 4
distal
117K SPK[R/K]RRSVSSQRSRSR 4
distal
120L SPKRRS[V/L]VSSQRSRSR 1
proximal
124S SPKRRSVSSQ[R/S]RSRSR 3
network-rewiring

PTM Site: 122S

Affected site:

Position: 122
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
128K PKRRSVSSQRSRS[R/K]RS 6
distal
128I PKRRSVSSQRSRS[R/I]RS 6
distal
120F PKRRS[V/F]VSSQRSRSRS 2
proximal
118I PKR[R/I]RSVSSQRSRSRS 4
distal
125F PKRRSVSSQR[S/F]SRSRS 3
network-rewiring
117K PK[R/K]RRSVSSQRSRSRS 5
network-rewiring
120L PKRRS[V/L]VSSQRSRSRS 2
proximal
124S PKRRSVSSQ[R/S]RSRSRS 2
network-rewiring

PTM Site: 125S

Affected site:

Position: 125
Residue: S
Type: phosphorylation

Impact:

distal

PTM Site: 132S

Affected site:

Position: 132
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
134I SRSRSRRSY[R/I]RSSRSP 2
proximal
131Q SRSRSR[R/Q]RSYRSSRSP 1
proximal
131W SRSRSR[R/W]RSYRSSRSP 1
proximal
130H SRSRS[R/H]RRSYRSSRSP 2
network-rewiring
137K SRSRSRRSYRSS[R/K]RSP 5
distal
128K SRS[R/K]RSRRSYRSSRSP 4
distal
131P SRSRSR[R/P]RSYRSSRSP 1
proximal
128I SRS[R/I]RSRRSYRSSRSP 4
distal
129A SRSR[S/A]SRRSYRSSRSP 3
network-rewiring
137M SRSRSRRSYRSS[R/M]RSP 5
distal

PTM Site: 133Y

Affected site:

Position: 133
Residue: Y
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
134I RSRSRRSY[R/I]RSSRSPR 1
proximal
131Q RSRSR[R/Q]RSYRSSRSPR 2
proximal
131W RSRSR[R/W]RSYRSSRSPR 2
proximal
130H RSRS[R/H]RRSYRSSRSPR 3
distal
137K RSRSRRSYRSS[R/K]RSPR 4
distal
128K RS[R/K]RSRRSYRSSRSPR 5
distal
131P RSRSR[R/P]RSYRSSRSPR 2
proximal
128I RS[R/I]RSRRSYRSSRSPR 5
distal
129A RSR[S/A]SRRSYRSSRSPR 4
distal
137M RSRSRRSYRSS[R/M]RSPR 4
distal

PTM Site: 135S

Affected site:

Position: 135
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
134I RSRRSY[R/I]RSSRSPRSS 1
proximal
131Q RSR[R/Q]RSYRSSRSPRSS 4
distal
131W RSR[R/W]RSYRSSRSPRSS 4
distal
130H RS[R/H]RRSYRSSRSPRSS 5
network-rewiring
137K RSRRSYRSS[R/K]RSPRSS 2
proximal
131P RSR[R/P]RSYRSSRSPRSS 4
distal
141L RSRRSYRSSRSPR[S/L]SS 6
distal
129A R[S/A]SRRSYRSSRSPRSS 6
distal
137M RSRRSYRSS[R/M]RSPRSS 2
network-rewiring

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