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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

BCLAF1 P235L

Summary

Isoform:
NM_001077441
Position:
235
Ref:
P
Mutation:
L
PTM impact:
network-rewiring
PTM affected:
3
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

STAD

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 228S

Affected site:

Position: 228
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
232V NSPRSPHSPSP[I/V]IATP 4
distal
228R NSPRSPH[S/R]SPSPIATP 0
direct
228N NSPRSPH[S/N]SPSPIATP 0
direct
224I NSP[R/I]RSPHSPSPIATP 4
distal
228I NSPRSPH[S/I]SPSPIATP 0
direct
230L NSPRSPHSP[S/L]SPIATP 2
proximal

PTM Site: 230S

Affected site:

Position: 230
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
232V PRSPHSPSP[I/V]IATPPS 2
proximal
228R PRSPH[S/R]SPSPIATPPS 2
network-rewiring
228N PRSPH[S/N]SPSPIATPPS 2
proximal
224I P[R/I]RSPHSPSPIATPPS 6
distal
236H PRSPHSPSPIATP[P/H]PS 6
distal
228I PRSPH[S/I]SPSPIATPPS 2
proximal
230L PRSPHSP[S/L]SPIATPPS 0
direct
236L PRSPHSPSPIATP[P/L]PS 6
distal
235L PRSPHSPSPIAT[P/L]PPS 5
distal

PTM Site: 234T

Affected site:

Position: 234
Residue: T
Type: phosphorylation

Only gain of PTM site:

PRKDC (probability p=0.982)
Site: 234T (phosphorylation)
Position in motif: 1

Best loss of PTM site:

MAPK10 (probability p=0.997)
Site: 234T (phosphorylation)
Position in motif: 1
There are 10 other predicted losses:
  • MAPK9 (p=0.983)
  • MAPK8 (p=0.963)
  • CDK5 (p=0.961)
  • GSK3B (p=0.96)
  • CDK2 (p=0.951)
  • MAPK14 (p=0.934)
  • HIPK2 (p=0.925)
  • CDK1 (p=0.901)
  • MAPK1 (p=0.893)
  • MAPK3 (p=0.88)

Other known mutations affecting this site

Mutation In sequence Distance Impact
232V HSPSP[I/V]IATPPSQSSS 2
proximal
228R H[S/R]SPSPIATPPSQSSS 6
distal
228N H[S/N]SPSPIATPPSQSSS 6
distal
236H HSPSPIATP[P/H]PSQSSS 2
proximal
228I H[S/I]SPSPIATPPSQSSS 6
distal
240P HSPSPIATPPSQS[S/P]SS 6
distal
237R HSPSPIATPP[S/R]SQSSS 3
network-rewiring
230L HSP[S/L]SPIATPPSQSSS 4
distal
236L HSPSPIATP[P/L]PSQSSS 2
proximal
235L HSPSPIAT[P/L]PPSQSSS 1
network-rewiring

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