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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

TP53 P20R

Summary

Isoform:
NM_001126116
Position:
20
Ref:
P
Mutation:
R
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
CSNK2A1, CSNK2A1, CSNK2A1

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Hereditary cancer-predisposing syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 17S

Affected site:

Position: 17
Residue: S
Type: phosphorylation, O-glycosylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
23S PVQLWVDSTPPPG[T/S]TR 6
distal
23N PVQLWVDSTPPPG[T/N]TR 6
distal
23A PVQLWVDSTPPPG[T/A]TR 6
distal
22V PVQLWVDSTPPP[G/V]GTR 5
distal
22D PVQLWVDSTPPP[G/D]GTR 5
distal
22R PVQLWVDSTPPP[G/R]GTR 5
distal
22S PVQLWVDSTPPP[G/S]GTR 5
distal
21L PVQLWVDSTPP[P/L]PGTR 4
distal
21S PVQLWVDSTPP[P/S]PGTR 4
network-rewiring
20L PVQLWVDSTP[P/L]PPGTR 3
distal
20R PVQLWVDSTP[P/R]PPGTR 3
distal
20S PVQLWVDSTP[P/S]PPGTR 3
distal
19R PVQLWVDST[P/R]PPPGTR 2
network-rewiring
19H PVQLWVDST[P/H]PPPGTR 2
proximal
19S PVQLWVDST[P/S]PPPGTR 2
proximal
19A PVQLWVDST[P/A]PPPGTR 2
proximal
19T PVQLWVDST[P/T]PPPGTR 2
proximal
17F PVQLWVD[S/F]STPPPGTR 0
direct
16A PVQLWV[D/A]DSTPPPGTR 1
proximal
16Y PVQLWV[D/Y]DSTPPPGTR 1
proximal
16N PVQLWV[D/N]DSTPPPGTR 1
proximal
15A PVQLW[V/A]VDSTPPPGTR 2
proximal
15I PVQLW[V/I]VDSTPPPGTR 2
proximal
14C PVQL[W/C]WVDSTPPPGTR 3
distal
14G PVQL[W/G]WVDSTPPPGTR 3
distal
13P PVQ[L/P]LWVDSTPPPGTR 4
distal
13Q PVQ[L/Q]LWVDSTPPPGTR 4
distal
12H PV[Q/H]QLWVDSTPPPGTR 5
distal
12L PV[Q/L]QLWVDSTPPPGTR 5
distal
12P PV[Q/P]QLWVDSTPPPGTR 5
distal
11G P[V/G]VQLWVDSTPPPGTR 6
distal
11A P[V/A]VQLWVDSTPPPGTR 6
distal
11L P[V/L]VQLWVDSTPPPGTR 6
distal
11M P[V/M]VQLWVDSTPPPGTR 6
distal
23I PVQLWVDSTPPPG[T/I]TR 6
distal
23P PVQLWVDSTPPPG[T/P]TR 6
distal
11E P[V/E]VQLWVDSTPPPGTR 6
distal
20Q PVQLWVDSTP[P/Q]PPGTR 3
distal
13R PVQ[L/R]LWVDSTPPPGTR 4
distal
14S PVQL[W/S]WVDSTPPPGTR 3
distal

PTM Site: 18T

Affected site:

Position: 18
Residue: T
Type: phosphorylation

Best gain of PTM site:

AKT1 (probability p=0.964)
Site: 23T (phosphorylation)
Position in motif: -3
There are 3 other predicted gains:
  • PRKACA (p=0.887)
  • PRKCB (p=0.878)
  • PRKAA1 (p=0.877)

Other known mutations affecting this site

Mutation In sequence Distance Impact
24P VQLWVDSTPPPGT[R/P]RV 6
distal
24H VQLWVDSTPPPGT[R/H]RV 6
distal
24C VQLWVDSTPPPGT[R/C]RV 6
distal
23S VQLWVDSTPPPG[T/S]TRV 5
distal
23N VQLWVDSTPPPG[T/N]TRV 5
distal
23A VQLWVDSTPPPG[T/A]TRV 5
distal
22V VQLWVDSTPPP[G/V]GTRV 4
distal
22D VQLWVDSTPPP[G/D]GTRV 4
distal
22R VQLWVDSTPPP[G/R]GTRV 4
distal
22S VQLWVDSTPPP[G/S]GTRV 4
distal
21L VQLWVDSTPP[P/L]PGTRV 3
distal
21S VQLWVDSTPP[P/S]PGTRV 3
distal
20L VQLWVDSTP[P/L]PPGTRV 2
proximal
20R VQLWVDSTP[P/R]PPGTRV 2
network-rewiring
20S VQLWVDSTP[P/S]PPGTRV 2
proximal
19R VQLWVDST[P/R]PPPGTRV 1
network-rewiring
19H VQLWVDST[P/H]PPPGTRV 1
network-rewiring
19S VQLWVDST[P/S]PPPGTRV 1
network-rewiring
19A VQLWVDST[P/A]PPPGTRV 1
network-rewiring
19T VQLWVDST[P/T]PPPGTRV 1
network-rewiring
17F VQLWVD[S/F]STPPPGTRV 1
proximal
16A VQLWV[D/A]DSTPPPGTRV 2
proximal
16Y VQLWV[D/Y]DSTPPPGTRV 2
proximal
16N VQLWV[D/N]DSTPPPGTRV 2
proximal
15A VQLW[V/A]VDSTPPPGTRV 3
distal
15I VQLW[V/I]VDSTPPPGTRV 3
distal
14C VQL[W/C]WVDSTPPPGTRV 4
distal
14G VQL[W/G]WVDSTPPPGTRV 4
distal
13P VQ[L/P]LWVDSTPPPGTRV 5
distal
13Q VQ[L/Q]LWVDSTPPPGTRV 5
distal
12H V[Q/H]QLWVDSTPPPGTRV 6
distal
12L V[Q/L]QLWVDSTPPPGTRV 6
distal
12P V[Q/P]QLWVDSTPPPGTRV 6
distal
23I VQLWVDSTPPPG[T/I]TRV 5
distal
23P VQLWVDSTPPPG[T/P]TRV 5
distal
24G VQLWVDSTPPPGT[R/G]RV 6
distal
20Q VQLWVDSTP[P/Q]PPGTRV 2
proximal
13R VQ[L/R]LWVDSTPPPGTRV 5
distal
14S VQL[W/S]WVDSTPPPGTRV 4
distal

PTM Site: 23T

Affected site:

Position: 23
Residue: T
Type: phosphorylation

Best gain of PTM site:

AKT1 (probability p=0.964)
Site: 23T (phosphorylation)
Position in motif: -3
There are 3 other predicted gains:
  • PRKACA (p=0.887)
  • PRKCB (p=0.878)
  • PRKAA1 (p=0.877)

Other known mutations affecting this site

Mutation In sequence Distance Impact
29D DSTPPPGTRVRAM[A/D]AI 6
distal
29T DSTPPPGTRVRAM[A/T]AI 6
distal
27V DSTPPPGTRVR[A/V]AMAI 4
distal
27P DSTPPPGTRVR[A/P]AMAI 4
distal
26L DSTPPPGTRV[R/L]RAMAI 3
distal
26P DSTPPPGTRV[R/P]RAMAI 3
distal
26H DSTPPPGTRV[R/H]RAMAI 3
distal
26C DSTPPPGTRV[R/C]RAMAI 3
distal
26G DSTPPPGTRV[R/G]RAMAI 3
distal
25G DSTPPPGTR[V/G]VRAMAI 2
proximal
25A DSTPPPGTR[V/A]VRAMAI 2
proximal
25D DSTPPPGTR[V/D]VRAMAI 2
proximal
25F DSTPPPGTR[V/F]VRAMAI 2
proximal
25I DSTPPPGTR[V/I]VRAMAI 2
proximal
24P DSTPPPGT[R/P]RVRAMAI 1
network-rewiring
24H DSTPPPGT[R/H]RVRAMAI 1
proximal
24C DSTPPPGT[R/C]RVRAMAI 1
proximal
23S DSTPPPG[T/S]TRVRAMAI 0
direct
23N DSTPPPG[T/N]TRVRAMAI 0
direct
23A DSTPPPG[T/A]TRVRAMAI 0
direct
22V DSTPPP[G/V]GTRVRAMAI 1
proximal
22D DSTPPP[G/D]GTRVRAMAI 1
proximal
22R DSTPPP[G/R]GTRVRAMAI 1
proximal
22S DSTPPP[G/S]GTRVRAMAI 1
proximal
21L DSTPP[P/L]PGTRVRAMAI 2
proximal
21S DSTPP[P/S]PGTRVRAMAI 2
proximal
20L DSTP[P/L]PPGTRVRAMAI 3
distal
20R DSTP[P/R]PPGTRVRAMAI 3
network-rewiring
20S DSTP[P/S]PPGTRVRAMAI 3
distal
19R DST[P/R]PPPGTRVRAMAI 4
distal
19H DST[P/H]PPPGTRVRAMAI 4
distal
19S DST[P/S]PPPGTRVRAMAI 4
distal
19A DST[P/A]PPPGTRVRAMAI 4
distal
19T DST[P/T]PPPGTRVRAMAI 4
distal
17F D[S/F]STPPPGTRVRAMAI 6
distal
23I DSTPPPG[T/I]TRVRAMAI 0
direct
23P DSTPPPG[T/P]TRVRAMAI 0
direct
24G DSTPPPGT[R/G]RVRAMAI 1
proximal
25L DSTPPPGTR[V/L]VRAMAI 2
proximal
29V DSTPPPGTRVRAM[A/V]AI 6
distal
20Q DSTP[P/Q]PPGTRVRAMAI 3
distal
29S DSTPPPGTRVRAM[A/S]AI 6
distal
28I DSTPPPGTRVRA[M/I]MAI 5
distal
29P DSTPPPGTRVRAM[A/P]AI 6
distal
26S DSTPPPGTRV[R/S]RAMAI 3
network-rewiring

External references

dbSNP:
rs587782705

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