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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

TP53 R26S

Summary

Isoform:
NM_001126116
Position:
26
Ref:
R
Mutation:
S
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
CSNK2A1

Clinical Information

Cancer types: (TCGA MC3)

LGG

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 23T

Affected site:

Position: 23
Residue: T
Type: phosphorylation

Only gain of PTM site:

CSNK1E (probability p=0.866)
Site: 23T (phosphorylation)
Position in motif: 3

Other known mutations affecting this site

Mutation In sequence Distance Impact
29D DSTPPPGTRVRAM[A/D]AI 6
distal
29T DSTPPPGTRVRAM[A/T]AI 6
distal
27V DSTPPPGTRVR[A/V]AMAI 4
distal
27P DSTPPPGTRVR[A/P]AMAI 4
distal
26L DSTPPPGTRV[R/L]RAMAI 3
distal
26P DSTPPPGTRV[R/P]RAMAI 3
distal
26H DSTPPPGTRV[R/H]RAMAI 3
distal
26C DSTPPPGTRV[R/C]RAMAI 3
distal
26G DSTPPPGTRV[R/G]RAMAI 3
distal
25G DSTPPPGTR[V/G]VRAMAI 2
proximal
25A DSTPPPGTR[V/A]VRAMAI 2
proximal
25D DSTPPPGTR[V/D]VRAMAI 2
proximal
25F DSTPPPGTR[V/F]VRAMAI 2
proximal
25I DSTPPPGTR[V/I]VRAMAI 2
proximal
24P DSTPPPGT[R/P]RVRAMAI 1
network-rewiring
24H DSTPPPGT[R/H]RVRAMAI 1
proximal
24C DSTPPPGT[R/C]RVRAMAI 1
proximal
23S DSTPPPG[T/S]TRVRAMAI 0
direct
23N DSTPPPG[T/N]TRVRAMAI 0
direct
23A DSTPPPG[T/A]TRVRAMAI 0
direct
22V DSTPPP[G/V]GTRVRAMAI 1
proximal
22D DSTPPP[G/D]GTRVRAMAI 1
proximal
22R DSTPPP[G/R]GTRVRAMAI 1
proximal
22S DSTPPP[G/S]GTRVRAMAI 1
proximal
21L DSTPP[P/L]PGTRVRAMAI 2
proximal
21S DSTPP[P/S]PGTRVRAMAI 2
proximal
20L DSTP[P/L]PPGTRVRAMAI 3
distal
20R DSTP[P/R]PPGTRVRAMAI 3
network-rewiring
20S DSTP[P/S]PPGTRVRAMAI 3
distal
19R DST[P/R]PPPGTRVRAMAI 4
distal
19H DST[P/H]PPPGTRVRAMAI 4
distal
19S DST[P/S]PPPGTRVRAMAI 4
distal
19A DST[P/A]PPPGTRVRAMAI 4
distal
19T DST[P/T]PPPGTRVRAMAI 4
distal
17F D[S/F]STPPPGTRVRAMAI 6
distal
23I DSTPPPG[T/I]TRVRAMAI 0
direct
23P DSTPPPG[T/P]TRVRAMAI 0
direct
24G DSTPPPGT[R/G]RVRAMAI 1
proximal
25L DSTPPPGTR[V/L]VRAMAI 2
proximal
29V DSTPPPGTRVRAM[A/V]AI 6
distal
20Q DSTP[P/Q]PPGTRVRAMAI 3
distal
29S DSTPPPGTRVRAM[A/S]AI 6
distal
28I DSTPPPGTRVRA[M/I]MAI 5
distal
29P DSTPPPGTRVRAM[A/P]AI 6
distal
26S DSTPPPGTRV[R/S]RAMAI 3
network-rewiring

PTM Site: 32K

Affected site:

Position: 32
Residue: K
Type: acetylation, ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
38M VRAMAIYKQSQHM[T/M]TE 6
distal
38R VRAMAIYKQSQHM[T/R]TE 6
distal
38A VRAMAIYKQSQHM[T/A]TE 6
distal
37I VRAMAIYKQSQH[M/I]MTE 5
distal
37R VRAMAIYKQSQH[M/R]MTE 5
distal
37V VRAMAIYKQSQH[M/V]MTE 5
distal
36R VRAMAIYKQSQ[H/R]HMTE 4
distal
35R VRAMAIYKQS[Q/R]QHMTE 3
distal
35P VRAMAIYKQS[Q/P]QHMTE 3
distal
34L VRAMAIYKQ[S/L]SQHMTE 2
proximal
33K VRAMAIYK[Q/K]QSQHMTE 1
proximal
32N VRAMAIY[K/N]KQSQHMTE 0
direct
32E VRAMAIY[K/E]KQSQHMTE 0
direct
31C VRAMAI[Y/C]YKQSQHMTE 1
proximal
31D VRAMAI[Y/D]YKQSQHMTE 1
proximal
31H VRAMAI[Y/H]YKQSQHMTE 1
proximal
31N VRAMAI[Y/N]YKQSQHMTE 1
proximal
30F VRAMA[I/F]IYKQSQHMTE 2
proximal
29D VRAM[A/D]AIYKQSQHMTE 3
distal
29T VRAM[A/T]AIYKQSQHMTE 3
distal
27V VR[A/V]AMAIYKQSQHMTE 5
distal
27P VR[A/P]AMAIYKQSQHMTE 5
distal
26L V[R/L]RAMAIYKQSQHMTE 6
distal
26P V[R/P]RAMAIYKQSQHMTE 6
distal
26H V[R/H]RAMAIYKQSQHMTE 6
distal
26C V[R/C]RAMAIYKQSQHMTE 6
distal
26G V[R/G]RAMAIYKQSQHMTE 6
distal
36L VRAMAIYKQSQ[H/L]HMTE 4
distal
29V VRAM[A/V]AIYKQSQHMTE 3
distal
29S VRAM[A/S]AIYKQSQHMTE 3
distal
28I VRA[M/I]MAIYKQSQHMTE 4
distal
30N VRAMA[I/N]IYKQSQHMTE 2
proximal
36P VRAMAIYKQSQ[H/P]HMTE 4
distal
29P VRAM[A/P]AIYKQSQHMTE 3
distal
26S V[R/S]RAMAIYKQSQHMTE 6
distal

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