You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
SAFB Y429H
Summary
Isoform:
Position:
429
Ref:
Y
Mutation:
H
PTM impact:
proximal
PTM affected:
4
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
READ
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 423K
Affected site:
Position: 423
Residue: K
Type: acetylation, ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 429C | TTRATDLKNLFSK[Y/C]YG | 6 |
distal
|
| 423N | TTRATDL[K/N]KNLFSKYG | 0 |
direct
|
| 429H | TTRATDLKNLFSK[Y/H]YG | 6 |
distal
|
PTM Site: 428K
Affected site:
Position: 428
Residue: K
Type: acetylation, ubiquitination
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 429C | DLKNLFSK[Y/C]YGKVVGA | 1 |
proximal
|
| 423N | DL[K/N]KNLFSKYGKVVGA | 5 |
distal
|
| 429H | DLKNLFSK[Y/H]YGKVVGA | 1 |
proximal
|
PTM Site: 431K
Affected site:
Position: 431
Residue: K
Type: ubiquitination
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 429C | NLFSK[Y/C]YGKVVGAKVV | 2 |
proximal
|
| 429H | NLFSK[Y/H]YGKVVGAKVV | 2 |
proximal
|
PTM Site: 436K
Affected site:
Position: 436
Residue: K
Type: acetylation, ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 439I | YGKVVGAKVV[T/I]TNARS | 3 |
distal
|
If you have any questions or feedback about this mutation:
Contact us