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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
CTNND1 P168R
Summary
Isoform:
Position:
168
Ref:
P
Mutation:
R
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
BRCA
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 163Y
Affected site:
Position: 163
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 161H | PDGYS[R/H]RHYEDGYPGG | 2 |
proximal
|
| 163C | PDGYSRH[Y/C]YEDGYPGG | 0 |
direct
|
| 168R | PDGYSRHYEDGY[P/R]PGG | 5 |
distal
|
PTM Site: 167Y
Affected site:
Position: 167
Residue: Y
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 161H | S[R/H]RHYEDGYPGGSDNY | 6 |
distal
|
| 163C | SRH[Y/C]YEDGYPGGSDNY | 4 |
distal
|
| 168R | SRHYEDGY[P/R]PGGSDNY | 1 |
proximal
|
PTM Site: 171S
Affected site:
Position: 171
Residue: S
Type: phosphorylation
Best gain of PTM site:
AKT1 (probability p=0.965)
Site: 171S (phosphorylation)
Position in motif: -3
There are 3 other predicted
gains:
- PRKACA (p=0.905)
- PRKCD (p=0.88)
- PRKAA1 (p=0.87)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 168R | EDGY[P/R]PGGSDNYGSLS | 3 |
network-rewiring
|
PTM Site: 174Y
Affected site:
Position: 174
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 179Q | YPGGSDNYGSLS[R/Q]RVT | 5 |
distal
|
| 168R | Y[P/R]PGGSDNYGSLSRVT | 6 |
distal
|
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