After several years of serving the research community, our ActiveDriverDB database will be retired on May 1st 2026. Please make sure to download any data you need and update your links or workflows before that date.
We want to sincerely thank all our users for their support, feedback, and collaboration over the years — your contributions have been invaluable to this project. A special thank you to Dr. Michal Krassowski for leading the development of our open-source software and database.
For any questions or assistance, please contact Jüri Reimand (juri.reimand@utoronto.ca).
You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
CTNND1 R179Q
Summary
Isoform:
Position:
179
Ref:
R
Mutation:
Q
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 174Y
Affected site:
Position: 174
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 179Q | YPGGSDNYGSLS[R/Q]RVT | 5 |
distal
|
| 168R | Y[P/R]PGGSDNYGSLSRVT | 6 |
distal
|
PTM Site: 176S
Affected site:
Position: 176
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 182C | GGSDNYGSLSRVT[R/C]RI | 6 |
distal
|
| 179Q | GGSDNYGSLS[R/Q]RVTRI | 3 |
distal
|
PTM Site: 178S
Affected site:
Position: 178
Residue: S
Type: phosphorylation
Best gain of PTM site:
ATM (probability p=0.963)
Site: 178S (phosphorylation)
Position in motif: 1
There are 2 other predicted
gains:
- ATR (p=0.926)
- PRKDC (p=0.868)
Best loss of PTM site:
PRKACA (probability p=0.959)
Site: 181T (phosphorylation)
Position in motif: -2
There are 3 other predicted
losses:
- AURKB (p=0.939)
- PRKCD (p=0.935)
- ROCK1 (p=0.891)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 182C | SDNYGSLSRVT[R/C]RIEE | 4 |
distal
|
| 179Q | SDNYGSLS[R/Q]RVTRIEE | 1 |
network-rewiring
|
PTM Site: 181T
Affected site:
Position: 181
Residue: T
Type: phosphorylation
Best gain of PTM site:
ATM (probability p=0.963)
Site: 178S (phosphorylation)
Position in motif: 1
There are 2 other predicted
gains:
- ATR (p=0.926)
- PRKDC (p=0.868)
Best loss of PTM site:
PRKACA (probability p=0.959)
Site: 181T (phosphorylation)
Position in motif: -2
There are 3 other predicted
losses:
- AURKB (p=0.939)
- PRKCD (p=0.935)
- ROCK1 (p=0.891)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 182C | YGSLSRVT[R/C]RIEERYR | 1 |
proximal
|
| 185G | YGSLSRVTRIE[E/G]ERYR | 4 |
distal
|
| 179Q | YGSLS[R/Q]RVTRIEERYR | 2 |
network-rewiring
|
If you have any questions or feedback about this mutation:
Contact us