After several years of serving the research community, our ActiveDriverDB database will be retired on May 1st 2026. Please make sure to download any data you need and update your links or workflows before that date.
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For any questions or assistance, please contact Jüri Reimand (juri.reimand@utoronto.ca).
You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
CTNND1 R261G
Summary
Isoform:
Position:
261
Ref:
R
Mutation:
G
PTM impact:
distal
PTM affected:
5
Kinases:
MAPK1,
MAPK3,
MAPK1,
MAPK3
Clinical Information
Cancer types: (TCGA MC3)
CESC
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 254T
Affected site:
Position: 254
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 253Q | DYGTAR[R/Q]RTGTPSDPR | 1 |
proximal
|
| 252H | DYGTA[R/H]RRTGTPSDPR | 2 |
network-rewiring
|
| 258C | DYGTARRTGTP[S/C]SDPR | 4 |
distal
|
PTM Site: 256T
Affected site:
Position: 256
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 253Q | GTAR[R/Q]RTGTPSDPRRR | 3 |
network-rewiring
|
| 261C | GTARRTGTPSDP[R/C]RRR | 5 |
distal
|
| 252H | GTA[R/H]RRTGTPSDPRRR | 4 |
distal
|
| 258C | GTARRTGTP[S/C]SDPRRR | 2 |
proximal
|
| 261G | GTARRTGTPSDP[R/G]RRR | 5 |
distal
|
PTM Site: 258S
Affected site:
Position: 258
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 253Q | AR[R/Q]RTGTPSDPRRRLR | 5 |
network-rewiring
|
| 261C | ARRTGTPSDP[R/C]RRRLR | 3 |
distal
|
| 252H | A[R/H]RRTGTPSDPRRRLR | 6 |
distal
|
| 263H | ARRTGTPSDPRR[R/H]RLR | 5 |
distal
|
| 258C | ARRTGTP[S/C]SDPRRRLR | 0 |
direct
|
| 261G | ARRTGTPSDP[R/G]RRRLR | 3 |
distal
|
PTM Site: 266S
Affected site:
Position: 266
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 261C | DP[R/C]RRRLRSYEDMIGE | 5 |
distal
|
| 263H | DPRR[R/H]RLRSYEDMIGE | 3 |
network-rewiring
|
| 261G | DP[R/G]RRRLRSYEDMIGE | 5 |
distal
|
PTM Site: 267Y
Affected site:
Position: 267
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 261C | P[R/C]RRRLRSYEDMIGEE | 6 |
distal
|
| 263H | PRR[R/H]RLRSYEDMIGEE | 4 |
distal
|
| 261G | P[R/G]RRRLRSYEDMIGEE | 6 |
distal
|
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