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Mutation:
CTNND1 R263H
Summary
Isoform:
Position:
263
Ref:
R
Mutation:
H
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
MAPK3,
MAPK1
Clinical Information
Cancer types: (TCGA MC3)
UCEC
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 256T
Affected site:
Position: 256
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 253Q | GTAR[R/Q]RTGTPSDPRRR | 3 |
network-rewiring
|
| 261C | GTARRTGTPSDP[R/C]RRR | 5 |
distal
|
| 252H | GTA[R/H]RRTGTPSDPRRR | 4 |
distal
|
| 258C | GTARRTGTP[S/C]SDPRRR | 2 |
proximal
|
| 261G | GTARRTGTPSDP[R/G]RRR | 5 |
distal
|
PTM Site: 258S
Affected site:
Position: 258
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 253Q | AR[R/Q]RTGTPSDPRRRLR | 5 |
network-rewiring
|
| 261C | ARRTGTPSDP[R/C]RRRLR | 3 |
distal
|
| 252H | A[R/H]RRTGTPSDPRRRLR | 6 |
distal
|
| 263H | ARRTGTPSDPRR[R/H]RLR | 5 |
distal
|
| 258C | ARRTGTP[S/C]SDPRRRLR | 0 |
direct
|
| 261G | ARRTGTPSDP[R/G]RRRLR | 3 |
distal
|
PTM Site: 266S
Affected site:
Position: 266
Residue: S
Type: phosphorylation
Best loss of PTM site:
RPS6KA1 (probability p=0.999)
Site: 266S (phosphorylation)
Position in motif: -3
There are 9 other predicted
losses:
- PAK1 (p=0.976)
- PRKACA (p=0.966)
- CAMK2A (p=0.947)
- CHEK1 (p=0.906)
- CAMK1 (p=0.906)
- PRKAA1 (p=0.902)
- PRKD1 (p=0.869)
- SGK1 (p=0.867)
- DAPK3 (p=0.864)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 261C | DP[R/C]RRRLRSYEDMIGE | 5 |
distal
|
| 263H | DPRR[R/H]RLRSYEDMIGE | 3 |
network-rewiring
|
| 261G | DP[R/G]RRRLRSYEDMIGE | 5 |
distal
|
PTM Site: 267Y
Affected site:
Position: 267
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 261C | P[R/C]RRRLRSYEDMIGEE | 6 |
distal
|
| 263H | PRR[R/H]RLRSYEDMIGEE | 4 |
distal
|
| 261G | P[R/G]RRRLRSYEDMIGEE | 6 |
distal
|
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