TRA2B R128W

You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

Mutation:

Summary

Isoform:

NM_001243879

Position:

128

Ref:

Mutation:

PTM impact:

direct

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

COAD

Cancer types: (PCAWG)

ColoRect-AdenoCA

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 124R

Affected site:

Position: 124

Residue: R

Type: methylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
119L	RR[R/L]RDYYDRGYDRGYD	5	distal
128W	RRRDYYDRGYD[R/W]RGYD	4	distal

PTM Site: 128R

Affected site:

Position: 128

Residue: R

Type: methylation

Impact:

direct

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
133W	YYDRGYDRGYDD[R/W]RDY	5	distal
128W	YYDRGYD[R/W]RGYDDRDY	0	direct

PTM Site: 133R

Affected site:

Position: 133

Residue: R

Type: methylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
138T	YDRGYDDRDYYS[R/T]RSY	5	distal
133W	YDRGYDD[R/W]RDYYSRSY	0	direct
128W	YD[R/W]RGYDDRDYYSRSY	5	distal
138K	YDRGYDDRDYYS[R/K]RSY	5	distal

PTM Site: 135Y

Affected site:

Position: 135

Residue: Y

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
138T	RGYDDRDYYS[R/T]RSYRG	3	distal
133W	RGYDD[R/W]RDYYSRSYRG	2	proximal
138K	RGYDDRDYYS[R/K]RSYRG	3	distal

If you have any questions or feedback about this mutation: