PDE3A L243F

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Mutation:

Summary

Isoform:

NM_001244683

Position:

243

Ref:

Mutation:

PTM impact:

distal

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

HNSC

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 236S

Affected site:

Position: 236

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
230V	A[D/V]DTTAKQSLGSHRAL	6	distal
237R	ADTTAKQS[L/R]LGSHRAL	1	proximal

PTM Site: 239S

Affected site:

Position: 239

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
237R	TAKQS[L/R]LGSHRALTYT	2	network-rewiring
244S	TAKQSLGSHRAL[T/S]TYT	5	distal
243F	TAKQSLGSHRA[L/F]LTYT	4	distal

PTM Site: 246T

Affected site:

Position: 246

Residue: T

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
247E	SHRALTYT[Q/E]QSAPDLS	1	network-rewiring
249V	SHRALTYTQS[A/V]APDLS	3	distal
250S	SHRALTYTQSA[P/S]PDLS	4	distal
244S	SHRAL[T/S]TYTQSAPDLS	2	proximal
243F	SHRA[L/F]LTYTQSAPDLS	3	distal
251H	SHRALTYTQSAP[D/H]DLS	5	distal

PTM Site: 248S

Affected site:

Position: 248

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
247E	RALTYT[Q/E]QSAPDLSPQ	1	proximal
249V	RALTYTQS[A/V]APDLSPQ	1	proximal
250S	RALTYTQSA[P/S]PDLSPQ	2	proximal
244S	RAL[T/S]TYTQSAPDLSPQ	4	distal
243F	RA[L/F]LTYTQSAPDLSPQ	5	distal
251H	RALTYTQSAP[D/H]DLSPQ	3	distal

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