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Mutation:
STX10 S134R
Summary
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0077]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 131K
Affected site:
Position: 131
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 134R | AGKPAAQKSP[S/R]SDLLD | 3 |
distal
|
PTM Site: 132S
Affected site:
Position: 132
Residue: S
Type: phosphorylation
Best gain of PTM site:
PRKCG (probability p=0.974)
Site: 132S (phosphorylation)
Position in motif: 2
There are 2 other predicted
gains:
- PRKCA (p=0.965)
- PRKCB (p=0.936)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 134R | GKPAAQKSP[S/R]SDLLDA | 2 |
network-rewiring
|
PTM Site: 134S
Affected site:
Position: 134
Residue: S
Type: phosphorylation
Impact:
directOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 134R | PAAQKSP[S/R]SDLLDASA | 0 |
direct
|
PTM Site: 140S
Affected site:
Position: 140
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 142I | PSDLLDASA[V/I]VSATSR | 2 |
proximal
|
| 141T | PSDLLDAS[A/T]AVSATSR | 1 |
proximal
|
| 134R | P[S/R]SDLLDASAVSATSR | 6 |
distal
|
| 143L | PSDLLDASAV[S/L]SATSR | 3 |
network-rewiring
|
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