STX10 V142I

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Mutation:

Summary

Isoform:

NM_001271610

Position:

142

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0077]

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 140S

Affected site:

Position: 140

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
142I	PSDLLDASA[V/I]VSATSR	2	proximal
141T	PSDLLDAS[A/T]AVSATSR	1	proximal
134R	P[S/R]SDLLDASAVSATSR	6	distal
143L	PSDLLDASAV[S/L]SATSR	3	network-rewiring

PTM Site: 143S

Affected site:

Position: 143

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
142I	LLDASA[V/I]VSATSRYIE	1	proximal
141T	LLDAS[A/T]AVSATSRYIE	2	proximal
149M	LLDASAVSATSRY[I/M]IE	6	distal
147C	LLDASAVSATS[R/C]RYIE	4	distal
143L	LLDASAV[S/L]SATSRYIE	0	direct

PTM Site: 145T

Affected site:

Position: 145

Residue: T

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
142I	DASA[V/I]VSATSRYIEEQ	3	distal
141T	DAS[A/T]AVSATSRYIEEQ	4	distal
149M	DASAVSATSRY[I/M]IEEQ	4	distal
147C	DASAVSATS[R/C]RYIEEQ	2	network-rewiring
143L	DASAV[S/L]SATSRYIEEQ	2	proximal

PTM Site: 146S

Affected site:

Position: 146

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
142I	ASA[V/I]VSATSRYIEEQQ	4	distal
141T	AS[A/T]AVSATSRYIEEQQ	5	distal
149M	ASAVSATSRY[I/M]IEEQQ	3	distal
147C	ASAVSATS[R/C]RYIEEQQ	1	proximal
143L	ASAV[S/L]SATSRYIEEQQ	3	distal

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