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Summary

Isoform:
Position:
331
Ref:
K
Mutation:
T
PTM impact:
direct
PTM affected:
6
Kinases:
NEK11

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Hereditary cancer-predisposing syndrome, Bloom syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 327T

Affected site:

Position: 327
Residue: T
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
323R STL[K/R]KDLDTSDRKEDV 4
distal
327S STLKDLD[T/S]TSDRKEDV 0
direct
329H STLKDLDTS[D/H]DRKEDV 2
proximal
331E STLKDLDTSDR[K/E]KEDV 4
distal
331T STLKDLDTSDR[K/T]KEDV 4
distal
332Q STLKDLDTSDRK[E/Q]EDV 5
distal
328C STLKDLDT[S/C]SDRKEDV 1
proximal

PTM Site: 328S

Affected site:

Position: 328
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
323R TL[K/R]KDLDTSDRKEDVL 5
distal
327S TLKDLD[T/S]TSDRKEDVL 1
proximal
329H TLKDLDTS[D/H]DRKEDVL 1
proximal
331E TLKDLDTSDR[K/E]KEDVL 3
network-rewiring
331T TLKDLDTSDR[K/T]KEDVL 3
distal
332Q TLKDLDTSDRK[E/Q]EDVL 4
distal
334D TLKDLDTSDRKED[V/D]VL 6
distal
328C TLKDLDT[S/C]SDRKEDVL 0
direct

PTM Site: 331K

Affected site:

Position: 331
Residue: K
Type: sumoylation, ubiquitination

Impact:

direct

Other known mutations affecting this site

Mutation In sequence Distance Impact
327S DLD[T/S]TSDRKEDVLSTS 4
distal
329H DLDTS[D/H]DRKEDVLSTS 2
proximal
331E DLDTSDR[K/E]KEDVLSTS 0
direct
331T DLDTSDR[K/T]KEDVLSTS 0
direct
332Q DLDTSDRK[E/Q]EDVLSTS 1
proximal
334D DLDTSDRKED[V/D]VLSTS 3
distal
335V DLDTSDRKEDV[L/V]LSTS 4
distal
336G DLDTSDRKEDVL[S/G]STS 5
distal
328C DLDT[S/C]SDRKEDVLSTS 3
distal

PTM Site: 336S

Affected site:

Position: 336
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
331E DR[K/E]KEDVLSTSKDLLS 5
distal
331T DR[K/T]KEDVLSTSKDLLS 5
distal
332Q DRK[E/Q]EDVLSTSKDLLS 4
distal
334D DRKED[V/D]VLSTSKDLLS 2
proximal
335V DRKEDV[L/V]LSTSKDLLS 1
proximal
336G DRKEDVL[S/G]STSKDLLS 0
direct
339E DRKEDVLSTS[K/E]KDLLS 3
network-rewiring
340N DRKEDVLSTSK[D/N]DLLS 4
distal
340H DRKEDVLSTSK[D/H]DLLS 4
distal
342S DRKEDVLSTSKDL[L/S]LS 6
distal

PTM Site: 337T

Affected site:

Position: 337
Residue: T
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
331E R[K/E]KEDVLSTSKDLLSK 6
distal
331T R[K/T]KEDVLSTSKDLLSK 6
distal
332Q RK[E/Q]EDVLSTSKDLLSK 5
distal
334D RKED[V/D]VLSTSKDLLSK 3
distal
335V RKEDV[L/V]LSTSKDLLSK 2
proximal
336G RKEDVL[S/G]STSKDLLSK 1
proximal
339E RKEDVLSTS[K/E]KDLLSK 2
network-rewiring
340N RKEDVLSTSK[D/N]DLLSK 3
network-rewiring
340H RKEDVLSTSK[D/H]DLLSK 3
network-rewiring
342S RKEDVLSTSKDL[L/S]LSK 5
distal
343A RKEDVLSTSKDLL[S/A]SK 6
distal

PTM Site: 338S

Affected site:

Position: 338
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
332Q K[E/Q]EDVLSTSKDLLSKP 6
distal
334D KED[V/D]VLSTSKDLLSKP 4
distal
335V KEDV[L/V]LSTSKDLLSKP 3
distal
336G KEDVL[S/G]STSKDLLSKP 2
proximal
339E KEDVLSTS[K/E]KDLLSKP 1
proximal
340N KEDVLSTSK[D/N]DLLSKP 2
proximal
340H KEDVLSTSK[D/H]DLLSKP 2
proximal
342S KEDVLSTSKDL[L/S]LSKP 4
distal
343A KEDVLSTSKDLL[S/A]SKP 5
distal
344N KEDVLSTSKDLLS[K/N]KP 6
distal

External references

dbSNP:

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