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Summary

Isoform:
Position:
339
Ref:
K
Mutation:
E
PTM impact:
direct
PTM affected:
6
Kinases:
NEK11

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Bloom syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 336S

Affected site:

Position: 336
Residue: S
Type: phosphorylation

Best gain of PTM site:

CSNK2A1 (probability p=0.951)
Site: 336S (phosphorylation)
Position in motif: 3
There is 1 other predicted gain:
  • CSNK2A2 (p=0.909)

Best loss of PTM site:

PRKCA (probability p=0.948)
Site: 337T (phosphorylation)
Position in motif: 2
There is 1 other predicted loss:
  • PRKCB (p=0.892)

Other known mutations affecting this site

Mutation In sequence Distance Impact
331E DR[K/E]KEDVLSTSKDLLS 5
distal
331T DR[K/T]KEDVLSTSKDLLS 5
distal
332Q DRK[E/Q]EDVLSTSKDLLS 4
distal
334D DRKED[V/D]VLSTSKDLLS 2
proximal
335V DRKEDV[L/V]LSTSKDLLS 1
proximal
336G DRKEDVL[S/G]STSKDLLS 0
direct
339E DRKEDVLSTS[K/E]KDLLS 3
network-rewiring
340N DRKEDVLSTSK[D/N]DLLS 4
distal
340H DRKEDVLSTSK[D/H]DLLS 4
distal
342S DRKEDVLSTSKDL[L/S]LS 6
distal

PTM Site: 337T

Affected site:

Position: 337
Residue: T
Type: phosphorylation

Best gain of PTM site:

CSNK2A1 (probability p=0.951)
Site: 336S (phosphorylation)
Position in motif: 3
There is 1 other predicted gain:
  • CSNK2A2 (p=0.909)

Best loss of PTM site:

PRKCA (probability p=0.948)
Site: 337T (phosphorylation)
Position in motif: 2
There is 1 other predicted loss:
  • PRKCB (p=0.892)

Other known mutations affecting this site

Mutation In sequence Distance Impact
331E R[K/E]KEDVLSTSKDLLSK 6
distal
331T R[K/T]KEDVLSTSKDLLSK 6
distal
332Q RK[E/Q]EDVLSTSKDLLSK 5
distal
334D RKED[V/D]VLSTSKDLLSK 3
distal
335V RKEDV[L/V]LSTSKDLLSK 2
proximal
336G RKEDVL[S/G]STSKDLLSK 1
proximal
339E RKEDVLSTS[K/E]KDLLSK 2
network-rewiring
340N RKEDVLSTSK[D/N]DLLSK 3
network-rewiring
340H RKEDVLSTSK[D/H]DLLSK 3
network-rewiring
342S RKEDVLSTSKDL[L/S]LSK 5
distal
343A RKEDVLSTSKDLL[S/A]SK 6
distal

PTM Site: 338S

Affected site:

Position: 338
Residue: S
Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
332Q K[E/Q]EDVLSTSKDLLSKP 6
distal
334D KED[V/D]VLSTSKDLLSKP 4
distal
335V KEDV[L/V]LSTSKDLLSKP 3
distal
336G KEDVL[S/G]STSKDLLSKP 2
proximal
339E KEDVLSTS[K/E]KDLLSKP 1
proximal
340N KEDVLSTSK[D/N]DLLSKP 2
proximal
340H KEDVLSTSK[D/H]DLLSKP 2
proximal
342S KEDVLSTSKDL[L/S]LSKP 4
distal
343A KEDVLSTSKDLL[S/A]SKP 5
distal
344N KEDVLSTSKDLLS[K/N]KP 6
distal

PTM Site: 339K

Affected site:

Position: 339
Residue: K
Type: ubiquitination

Impact:

direct

Other known mutations affecting this site

Mutation In sequence Distance Impact
334D ED[V/D]VLSTSKDLLSKPE 5
distal
335V EDV[L/V]LSTSKDLLSKPE 4
distal
336G EDVL[S/G]STSKDLLSKPE 3
distal
339E EDVLSTS[K/E]KDLLSKPE 0
direct
340N EDVLSTSK[D/N]DLLSKPE 1
proximal
340H EDVLSTSK[D/H]DLLSKPE 1
proximal
342S EDVLSTSKDL[L/S]LSKPE 3
distal
343A EDVLSTSKDLL[S/A]SKPE 4
distal
344N EDVLSTSKDLLS[K/N]KPE 5
distal

PTM Site: 343S

Affected site:

Position: 343
Residue: S
Type: phosphorylation

Impact:

distal

PTM Site: 344K

Affected site:

Position: 344
Residue: K
Type: sumoylation, ubiquitination

Impact:

distal

External references

dbSNP:

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