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Mutation:
CSN2 L22I
Summary
Isoform:
Position:
22
Ref:
L
Mutation:
I
PTM impact:
network-rewiring
PTM affected:
5
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
LUAD
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 18T
Affected site:
Position: 18
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 22I | ALALARETIES[L/I]LSSS | 4 |
distal
|
PTM Site: 21S
Affected site:
Position: 21
Residue: S
Type: phosphorylation
Best loss of PTM site:
PRKDC (probability p=0.959)
Site: 21S (phosphorylation)
Position in motif: 1
There is 1 other predicted
loss:
- STK11 (p=0.891)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 22I | LARETIES[L/I]LSSSEES | 1 |
network-rewiring
|
| 26Q | LARETIESLSSS[E/Q]EES | 5 |
distal
|
PTM Site: 23S
Affected site:
Position: 23
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 22I | RETIES[L/I]LSSSEESIT | 1 |
proximal
|
| 26Q | RETIESLSSS[E/Q]EESIT | 3 |
network-rewiring
|
PTM Site: 24S
Affected site:
Position: 24
Residue: S
Type: phosphorylation
Best loss of PTM site:
PRKDC (probability p=0.959)
Site: 21S (phosphorylation)
Position in motif: 1
There is 1 other predicted
loss:
- STK11 (p=0.891)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 22I | ETIES[L/I]LSSSEESITE | 2 |
network-rewiring
|
| 26Q | ETIESLSSS[E/Q]EESITE | 2 |
proximal
|
PTM Site: 25S
Affected site:
Position: 25
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 22I | TIES[L/I]LSSSEESITEY | 3 |
distal
|
| 26Q | TIESLSSS[E/Q]EESITEY | 1 |
network-rewiring
|
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