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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

CSN2 E26Q

Summary

Isoform:
NM_001891
Position:
26
Ref:
E
Mutation:
Q
PTM impact:
network-rewiring
PTM affected:
4
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

BRCA

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 21S

Affected site:

Position: 21
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
22I LARETIES[L/I]LSSSEES 1
network-rewiring
26Q LARETIESLSSS[E/Q]EES 5
distal

PTM Site: 23S

Affected site:

Position: 23
Residue: S
Type: phosphorylation

Best gain of PTM site:

ATM (probability p=0.996)
Site: 25S (phosphorylation)
Position in motif: 1
There is 1 other predicted gain:
  • PRKDC (p=0.974)

Best loss of PTM site:

CSNK2A1 (probability p=0.958)
Site: 23S (phosphorylation)
Position in motif: 3
There is 1 other predicted loss:
  • CSNK2A2 (p=0.943)

Other known mutations affecting this site

Mutation In sequence Distance Impact
22I RETIES[L/I]LSSSEESIT 1
proximal
26Q RETIESLSSS[E/Q]EESIT 3
network-rewiring

PTM Site: 24S

Affected site:

Position: 24
Residue: S
Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
22I ETIES[L/I]LSSSEESITE 2
network-rewiring
26Q ETIESLSSS[E/Q]EESITE 2
proximal

PTM Site: 25S

Affected site:

Position: 25
Residue: S
Type: phosphorylation

Best gain of PTM site:

ATM (probability p=0.996)
Site: 25S (phosphorylation)
Position in motif: 1
There is 1 other predicted gain:
  • PRKDC (p=0.974)

Best loss of PTM site:

CSNK2A1 (probability p=0.958)
Site: 23S (phosphorylation)
Position in motif: 3
There is 1 other predicted loss:
  • CSNK2A2 (p=0.943)

Other known mutations affecting this site

Mutation In sequence Distance Impact
22I TIES[L/I]LSSSEESITEY 3
distal
26Q TIESLSSS[E/Q]EESITEY 1
network-rewiring

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