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Mutation:
MDM2 S259Y
Summary
Isoform:
Position:
259
Ref:
S
Mutation:
Y
PTM impact:
direct
PTM affected:
4
Kinases:
CSNK1D,
CSNK1D,
CSNK2A1,
PLK1
Clinical Information
Cancer types: (TCGA MC3)
HNSC
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 252S
Affected site:
Position: 252
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 246L | D[S/L]SVSDQFSVEFEVES | 6 |
distal
|
PTM Site: 259S
Affected site:
Position: 259
Residue: S
Type: phosphorylation
Impact:
directOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 261N | SVEFEVESL[D/N]DSEDYS | 2 |
proximal
|
| 259Y | SVEFEVE[S/Y]SLDSEDYS | 0 |
direct
|
PTM Site: 262S
Affected site:
Position: 262
Residue: S
Type: phosphorylation
Best loss of PTM site:
CSNK1D (probability p=0.961)
Site: 262S (phosphorylation)
Position in motif: -3
There is 1 other predicted
loss:
- CSNK1A1 (p=0.883)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 261N | FEVESL[D/N]DSEDYSLSE | 1 |
proximal
|
| 259Y | FEVE[S/Y]SLDSEDYSLSE | 3 |
network-rewiring
|
PTM Site: 266S
Affected site:
Position: 266
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 261N | SL[D/N]DSEDYSLSEEGQE | 5 |
distal
|
| 270D | SLDSEDYSLSE[E/D]EGQE | 4 |
distal
|
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