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Mutation:
MDM2 E270D
Summary
Isoform:
Position:
270
Ref:
E
Mutation:
D
PTM impact:
proximal
PTM affected:
3
Kinases:
CSNK2A1,
CSNK1D,
PLK1,
CSNK1D,
CSNK2A1,
CSNK1D
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 266S
Affected site:
Position: 266
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 261N | SL[D/N]DSEDYSLSEEGQE | 5 |
distal
|
| 270D | SLDSEDYSLSE[E/D]EGQE | 4 |
distal
|
PTM Site: 268S
Affected site:
Position: 268
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 273A | DSEDYSLSEEGQ[E/A]ELS | 5 |
distal
|
| 270D | DSEDYSLSE[E/D]EGQELS | 2 |
proximal
|
PTM Site: 275S
Affected site:
Position: 275
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 273A | SEEGQ[E/A]ELSDEDDEVY | 2 |
network-rewiring
|
| 281L | SEEGQELSDEDDE[V/L]VY | 6 |
distal
|
| 270D | SE[E/D]EGQELSDEDDEVY | 5 |
distal
|
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