You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
MDM2 E273A
Summary
Isoform:
Position:
273
Ref:
E
Mutation:
A
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
PLK1,
CSNK2A1,
CSNK1D,
CSNK1D,
CSNK2A1,
CSNK1D
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0253]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 266S
Affected site:
Position: 266
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 261N | SL[D/N]DSEDYSLSEEGQE | 5 |
distal
|
| 270D | SLDSEDYSLSE[E/D]EGQE | 4 |
distal
|
PTM Site: 268S
Affected site:
Position: 268
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 273A | DSEDYSLSEEGQ[E/A]ELS | 5 |
distal
|
| 270D | DSEDYSLSE[E/D]EGQELS | 2 |
proximal
|
PTM Site: 275S
Affected site:
Position: 275
Residue: S
Type: phosphorylation
Only loss of PTM site:
PLK1 (probability p=0.981)
Site: 275S (phosphorylation)
Position in motif: -2
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 273A | SEEGQ[E/A]ELSDEDDEVY | 2 |
network-rewiring
|
| 281L | SEEGQELSDEDDE[V/L]VY | 6 |
distal
|
| 270D | SE[E/D]EGQELSDEDDEVY | 5 |
distal
|
If you have any questions or feedback about this mutation:
Contact us