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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

PYGB D7Y

Summary

Isoform:
NM_002862
Position:
7
Ref:
D
Mutation:
Y
PTM impact:
proximal
PTM affected:
5
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

Eso-AdenoCa

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 2A

Affected site:

Position: 2
Residue: A
Type: acetylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
2T ------M[A/T]AKPLTDSE 0
direct
4S ------MAK[P/S]PLTDSE 2
proximal
8C ------MAKPLTD[S/C]SE 6
distal
7Y ------MAKPLT[D/Y]DSE 5
distal

PTM Site: 3K

Affected site:

Position: 3
Residue: K
Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
2T -----M[A/T]AKPLTDSEK 1
proximal
4S -----MAK[P/S]PLTDSEK 1
proximal
8C -----MAKPLTD[S/C]SEK 5
distal
7Y -----MAKPLT[D/Y]DSEK 4
distal

PTM Site: 6T

Affected site:

Position: 6
Residue: T
Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
2T --M[A/T]AKPLTDSEKRKQ 4
distal
4S --MAK[P/S]PLTDSEKRKQ 2
proximal
8C --MAKPLTD[S/C]SEKRKQ 2
proximal
7Y --MAKPLT[D/Y]DSEKRKQ 1
proximal

PTM Site: 8S

Affected site:

Position: 8
Residue: S
Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
2T M[A/T]AKPLTDSEKRKQIS 6
distal
4S MAK[P/S]PLTDSEKRKQIS 4
distal
8C MAKPLTD[S/C]SEKRKQIS 0
direct
7Y MAKPLT[D/Y]DSEKRKQIS 1
proximal

PTM Site: 10K

Affected site:

Position: 10
Residue: K
Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
4S K[P/S]PLTDSEKRKQISVR 6
distal
8C KPLTD[S/C]SEKRKQISVR 2
proximal
7Y KPLT[D/Y]DSEKRKQISVR 3
distal

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