You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
ABL1 G303R
Summary
Isoform:
Position:
303
Ref:
G
Mutation:
R
PTM impact:
network-rewiring
PTM affected:
1
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
SKCM
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 306T
Affected site:
Position: 306
Residue: T
Type: phosphorylation
Best gain of PTM site:
CHEK2 (probability p=0.979)
Site: 306T (phosphorylation)
Position in motif: -3
There are 7 other predicted
gains:
- AKT1 (p=0.969)
- CHEK1 (p=0.964)
- CAMK2A (p=0.925)
- PAK1 (p=0.907)
- MAPKAPK2 (p=0.889)
- PRKAA1 (p=0.872)
- CAMK2G (p=0.863)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 311L | VQLLGVCTREPP[F/L]FYI | 5 |
distal
|
| 303R | VQLL[G/R]GVCTREPPFYI | 3 |
network-rewiring
|
| 310T | VQLLGVCTREP[P/T]PFYI | 4 |
distal
|
| 310L | VQLLGVCTREP[P/L]PFYI | 4 |
distal
|
| 312C | VQLLGVCTREPPF[Y/C]YI | 6 |
distal
|
If you have any questions or feedback about this mutation:
Contact us