MRE11A T439I

After several years of serving the research community, our ActiveDriverDB database will be retired on May 1st 2026. Please make sure to download any data you need and update your links or workflows before that date.

We want to sincerely thank all our users for their support, feedback, and collaboration over the years — your contributions have been invaluable to this project. A special thank you to Dr. Michal Krassowski for leading the development of our open-source software and database.

For any questions or assistance, please contact Jüri Reimand (juri.reimand@utoronto.ca).

You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

Mutation:

Summary

Isoform:

NM_005591

Position:

439

Ref:

Mutation:

PTM impact:

distal

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Hereditary cancer-predisposing syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 434K

Affected site:

Position: 434

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
440S	LRVEDLVKQYFQT[A/S]AE	6	distal
440T	LRVEDLVKQYFQT[A/T]AE	6	distal
439I	LRVEDLVKQYFQ[T/I]TAE	5	distal
438E	LRVEDLVKQYF[Q/E]QTAE	4	distal
436H	LRVEDLVKQ[Y/H]YFQTAE	2	proximal
436N	LRVEDLVKQ[Y/N]YFQTAE	2	proximal
435H	LRVEDLVK[Q/H]QYFQTAE	1	proximal
430V	LRV[E/V]EDLVKQYFQTAE	4	distal
429A	LR[V/A]VEDLVKQYFQTAE	5	distal
428G	L[R/G]RVEDLVKQYFQTAE	6	distal

PTM Site: 436Y

Affected site:

Position: 436

Residue: Y

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
440S	VEDLVKQYFQT[A/S]AEKN	4	distal
440T	VEDLVKQYFQT[A/T]AEKN	4	distal
439I	VEDLVKQYFQ[T/I]TAEKN	3	distal
438E	VEDLVKQYF[Q/E]QTAEKN	2	proximal
436H	VEDLVKQ[Y/H]YFQTAEKN	0	direct
436N	VEDLVKQ[Y/N]YFQTAEKN	0	direct
435H	VEDLVK[Q/H]QYFQTAEKN	1	proximal
430V	V[E/V]EDLVKQYFQTAEKN	6	distal

PTM Site: 442K

Affected site:

Position: 442

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
445R	QYFQTAEKNV[Q/R]QLSLL	3	distal
440S	QYFQT[A/S]AEKNVQLSLL	2	proximal
440T	QYFQT[A/T]AEKNVQLSLL	2	proximal
439I	QYFQ[T/I]TAEKNVQLSLL	3	distal
438E	QYF[Q/E]QTAEKNVQLSLL	4	distal
436H	Q[Y/H]YFQTAEKNVQLSLL	6	distal
436N	Q[Y/N]YFQTAEKNVQLSLL	6	distal

External references

dbSNP:

rs1555009844

If you have any questions or feedback about this mutation: