After several years of serving the research community, our ActiveDriverDB database will be retired on May 1st 2026. Please make sure to download any data you need and update your links or workflows before that date.
We want to sincerely thank all our users for their support, feedback, and collaboration over the years — your contributions have been invaluable to this project. A special thank you to Dr. Michal Krassowski for leading the development of our open-source software and database.
For any questions or assistance, please contact Jüri Reimand (juri.reimand@utoronto.ca).
You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
MRE11A Q445R
Summary
Isoform:
Position:
445
Ref:
Q
Mutation:
R
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
[0.0077]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 442K
Affected site:
Position: 442
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 445R | QYFQTAEKNV[Q/R]QLSLL | 3 |
distal
|
| 440S | QYFQT[A/S]AEKNVQLSLL | 2 |
proximal
|
| 440T | QYFQT[A/T]AEKNVQLSLL | 2 |
proximal
|
| 439I | QYFQ[T/I]TAEKNVQLSLL | 3 |
distal
|
| 438E | QYF[Q/E]QTAEKNVQLSLL | 4 |
distal
|
| 436H | Q[Y/H]YFQTAEKNVQLSLL | 6 |
distal
|
| 436N | Q[Y/N]YFQTAEKNVQLSLL | 6 |
distal
|
PTM Site: 447S
Affected site:
Position: 447
Residue: S
Type: phosphorylation
Best gain of PTM site:
AURKA (probability p=0.994)
Site: 447S (phosphorylation)
Position in motif: -2
There are 4 other predicted
gains:
- PRKACA (p=0.957)
- AURKB (p=0.934)
- PRKG1 (p=0.891)
- ROCK1 (p=0.88)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 453A | AEKNVQLSLLTER[G/A]GM | 6 |
distal
|
| 445R | AEKNV[Q/R]QLSLLTERGM | 2 |
network-rewiring
|
| 453W | AEKNVQLSLLTER[G/W]GM | 6 |
distal
|
| 451Q | AEKNVQLSLLT[E/Q]ERGM | 4 |
distal
|
External references
dbSNP:
If you have any questions or feedback about this mutation:
Contact us