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Mutation:
GIPC1 R224C
Summary
Isoform:
Position:
224
Ref:
R
Mutation:
C
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 222S
Affected site:
Position: 222
Residue: S
Type: phosphorylation
Only loss of PTM site:
PRKCG (probability p=0.864)
Site: 222S (phosphorylation)
Position in motif: 2
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 226V | RKAFDMISQRS[A/V]AGGR | 4 |
distal
|
| 224C | RKAFDMISQ[R/C]RSAGGR | 2 |
network-rewiring
|
PTM Site: 225S
Affected site:
Position: 225
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 231S | FDMISQRSAGGRP[G/S]GS | 6 |
distal
|
| 226V | FDMISQRS[A/V]AGGRPGS | 1 |
proximal
|
| 224C | FDMISQ[R/C]RSAGGRPGS | 1 |
proximal
|
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