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Mutation:
CYLD T393A
Summary
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 387S
Affected site:
Position: 387
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 389R | VAEDPAKSL[T/R]TEISTD | 2 |
network-rewiring
|
| 391T | VAEDPAKSLTE[I/T]ISTD | 4 |
distal
|
| 393A | VAEDPAKSLTEIS[T/A]TD | 6 |
distal
|
| 390V | VAEDPAKSLT[E/V]EISTD | 3 |
network-rewiring
|
| 388F | VAEDPAKS[L/F]LTEISTD | 1 |
network-rewiring
|
| 393I | VAEDPAKSLTEIS[T/I]TD | 6 |
distal
|
PTM Site: 389T
Affected site:
Position: 389
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 389R | EDPAKSL[T/R]TEISTDFD | 0 |
direct
|
| 391T | EDPAKSLTE[I/T]ISTDFD | 2 |
proximal
|
| 393A | EDPAKSLTEIS[T/A]TDFD | 4 |
distal
|
| 390V | EDPAKSLT[E/V]EISTDFD | 1 |
proximal
|
| 388F | EDPAKS[L/F]LTEISTDFD | 1 |
proximal
|
| 393I | EDPAKSLTEIS[T/I]TDFD | 4 |
distal
|
PTM Site: 393T
Affected site:
Position: 393
Residue: T
Type: phosphorylation
Impact:
directOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 389R | KSL[T/R]TEISTDFDRSSP | 4 |
distal
|
| 391T | KSLTE[I/T]ISTDFDRSSP | 2 |
proximal
|
| 397C | KSLTEISTDFD[R/C]RSSP | 4 |
distal
|
| 397H | KSLTEISTDFD[R/H]RSSP | 4 |
distal
|
| 398A | KSLTEISTDFDR[S/A]SSP | 5 |
distal
|
| 393A | KSLTEIS[T/A]TDFDRSSP | 0 |
direct
|
| 390V | KSLT[E/V]EISTDFDRSSP | 3 |
distal
|
| 388F | KS[L/F]LTEISTDFDRSSP | 5 |
distal
|
| 393I | KSLTEIS[T/I]TDFDRSSP | 0 |
direct
|
PTM Site: 399S
Affected site:
Position: 399
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 397C | STDFD[R/C]RSSPPLQPPP | 2 |
network-rewiring
|
| 397H | STDFD[R/H]RSSPPLQPPP | 2 |
network-rewiring
|
| 398A | STDFDR[S/A]SSPPLQPPP | 1 |
proximal
|
| 393A | S[T/A]TDFDRSSPPLQPPP | 6 |
distal
|
| 393I | S[T/I]TDFDRSSPPLQPPP | 6 |
distal
|
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