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Mutation:
DTL F497L
Summary
Isoform:
Position:
497
Ref:
F
Mutation:
L
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
BLCA
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 490S
Affected site:
Position: 490
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 489I | RGSVSS[V/I]VSPKPPSSF | 1 |
proximal
|
| 486L | RGS[V/L]VSSVSPKPPSSF | 4 |
distal
|
| 493L | RGSVSSVSPK[P/L]PPSSF | 3 |
distal
|
PTM Site: 495S
Affected site:
Position: 495
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 489I | S[V/I]VSPKPPSSFKMSIR | 6 |
distal
|
| 499K | SVSPKPPSSFK[M/K]MSIR | 4 |
distal
|
| 493L | SVSPK[P/L]PPSSFKMSIR | 2 |
proximal
|
| 497L | SVSPKPPSS[F/L]FKMSIR | 2 |
proximal
|
PTM Site: 496S
Affected site:
Position: 496
Residue: S
Type: phosphorylation
Only loss of PTM site:
PDPK1 (probability p=0.851)
Site: 496S (phosphorylation)
Position in motif: 1
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 499K | VSPKPPSSFK[M/K]MSIRN | 3 |
distal
|
| 493L | VSPK[P/L]PPSSFKMSIRN | 3 |
distal
|
| 497L | VSPKPPSS[F/L]FKMSIRN | 1 |
network-rewiring
|
PTM Site: 498K
Affected site:
Position: 498
Residue: K
Type: ubiquitination
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 499K | PKPPSSFK[M/K]MSIRNWV | 1 |
proximal
|
| 493L | PK[P/L]PPSSFKMSIRNWV | 5 |
distal
|
| 497L | PKPPSS[F/L]FKMSIRNWV | 1 |
proximal
|
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