DTL M499K

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Mutation:

Summary

Isoform:

NM_016448

Position:

499

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0077]

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 495S

Affected site:

Position: 495

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
489I	S[V/I]VSPKPPSSFKMSIR	6	distal
499K	SVSPKPPSSFK[M/K]MSIR	4	distal
493L	SVSPK[P/L]PPSSFKMSIR	2	proximal
497L	SVSPKPPSS[F/L]FKMSIR	2	proximal

PTM Site: 496S

Affected site:

Position: 496

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
499K	VSPKPPSSFK[M/K]MSIRN	3	distal
493L	VSPK[P/L]PPSSFKMSIRN	3	distal
497L	VSPKPPSS[F/L]FKMSIRN	1	network-rewiring

PTM Site: 498K

Affected site:

Position: 498

Residue: K

Type: ubiquitination

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
499K	PKPPSSFK[M/K]MSIRNWV	1	proximal
493L	PK[P/L]PPSSFKMSIRNWV	5	distal
497L	PKPPSS[F/L]FKMSIRNWV	1	proximal

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